Allele-specific associations of 5-HTTLPR/rs25531 with ADHD and autism spectrum disorder.

ABSTRACT:

Background

The aims of the present study were to examine the association between a common serotonin transporter gene (SLC6A4) polymorphism 5-HTTLPR/rs25531 with severity of attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) symptoms.

Methods

Mothers and teachers completed a validated DSM-IV-referenced rating scale for ADHD and ASD symptoms in 118 children with ASD.

Results

Analyses indicated that children with at least one copy of the S or L(G) allele obtained significantly more severe maternal ratings of hyperactivity (p=0.001; ηp(2)=0.097) and impulsivity (p=0.027; ηp(2)=0.044) but not inattention (p=0.061; ηp(2)=0.032), controlling for ASD severity, than children homozygous for the L(A) allele. Conversely, mothers' ratings indicated

SUBMITTER: Gadow KD 

PROVIDER: S-EPMC3522768 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature