Mass transport effects in suspended waveguide biosensors integrated in microfluidic channels.

ABSTRACT: Label-free optical biosensors based on integrated photonic devices have demonstrated sensitive and selective detection of biological analytes. Integrating these sensor platforms into microfluidic devices reduces the required sample volume and enables rapid delivery of sample to the sensor surface, thereby improving response times. Conventionally, these devices are embedded in or adjacent to the substrate; therefore, the effective sensing area lies within the slow-flow region at the floor of the channel, reducing the efficiency of sample delivery. Recently, a suspended waveguide sensor was developed in which the device is elevated off of the substrate and the sensing region does not rest on the substrate. This geometry places the sensing region in the middle of the parabolic velocity profi

SUBMITTER: Murthy CR 

PROVIDER: S-EPMC3522916 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature