A tool to facilitate clinical biomarker studies--a tissue dictionary based on the Human Protein Atlas.

ABSTRACT: The complexity of tissue and the alterations that distinguish normal from cancer remain a challenge for translating results from tumor biological studies into clinical medicine. This has generated an unmet need to exploit the findings from studies based on cell lines and model organisms to develop, validate and clinically apply novel diagnostic, prognostic and treatment predictive markers. As one step to meet this challenge, the Human Protein Atlas project has been set up to produce antibodies towards human protein targets corresponding to all human protein coding genes and to map protein expression in normal human tissues, cancer and cells. Here, we present a dictionary based on microscopy images created as an amendment to the Human Protein Atlas. The aim of the dictionary is to facilitat

SUBMITTER: Kampf C 

PROVIDER: S-EPMC3523031 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature