Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue.

ABSTRACT:

Background

Periprostatic (PP) adipose tissue surrounds the prostate, an organ with a high predisposition to become malignant. Frequently, growing prostatic tumor cells extend beyond the prostatic organ towards this fat depot. This study aimed to determine the genome-wide expression of genes in PP adipose tissue in obesity/overweight (OB/OW) and prostate cancer patients.

Methods

Differentially expressed genes in human PP adipose tissue were identified using microarrays. Analyses were conducted according to the donors' body mass index characteristics (OB/OW versus lean) and prostate disease (extra prostatic cancer versus organ confined prostate cancer versus benign prostatic hyperplasia). Selected genes with altered expression were validated by real-time PCR. Ingenuity Pathway

SUBMITTER: Ribeiro R 

PROVIDER: S-EPMC3523039 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature