Integrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma.

ABSTRACT:

Purpose

Esophageal adenocarcinoma (EAC) is a lethal malignancy that can develop from the premalignant condition, Barrett's esophagus (BE). Currently, there are no validated simple methods to predict which patients will progress to EAC. A better understanding of the genetic mechanisms driving EAC tumorigenesis is needed to identify new therapeutic targets and develop biomarkers capable of identifying high-risk patients that would benefit from aggressive neoadjuvant therapy. We employed an integrative genomics approach to identify novel genes involved in EAC biology that may serve as useful clinical markers.

Experimental design

Whole genome tiling-path array comparative genomic hybridization was used to identify significant regions of copy number alteration in 20 EACs and 10 m

SUBMITTER: Lockwood WW 

PROVIDER: S-EPMC3523177 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature