Chemoselective ligation of sulfinic acids with aryl-nitroso compounds.

ABSTRACT: Making a comeback: The inefficient condensation of sulfinic acid and aryl nitroso compounds has been transformed into a chemoselective process that converts sulfinic acid into stable cyclic sulfonamide analogues (see scheme). This ligation proceeds rapidly under aqueous conditions in high yield, and lays the groundwork for the development of sulfinic acid detection methods in biological systems.

SUBMITTER: Lo Conte M 

PROVIDER: S-EPMC3523331 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature