Association of MTHFR C677T and A1298C gene polymorphisms with hypertension.

ABSTRACT:

Objectives

To check for the association of genetic polymorphisms related to the methylenetetrahydrofolate reductase (MTHFR) gene namely C677T and A1298C with hypertension in Saudi affected subjects from Qassim region.

Subjects and methods

Participants included 123 Saudi hypertensive cases (83 males and 40 females) in addition to 250 (142 males and 108 females) unrelated healthy controls from the same locality. Their age mean ±SD was 50.93 ± 15.43 years. For all subjects, DNA was extracted followed by real-time PCR amplifications for characterization of genotypes and alleles related to MTHFR C677T and A1298C gene polymorphisms

Results

Total cases showed significantly higher carriage rate for the mutant allele 677T compared to controls (40.7% vs. 26%, OR=1.9, 95% CI= 1.

SUBMITTER: Alghasham A 

PROVIDER: S-EPMC3523778 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature