Systematic review and meta-analysis on the association between outpatient statins use and infectious disease-related mortality.

ABSTRACT:

Background

To update and refine systematic literature review on the association between outpatient statins use and mortality in patients with infectious disease.

Materials and methods

We searched articles published before September 31, 2012, on the association between statins and infectious disease-related mortality through electronic databases. Eligible articles were analyzed in Review Manager 5.1. We conducted stratification analysis by study design, infection types, clinical outcomes and study locations.

Results

The pooled odds ratio (OR) for death (statins use vs. no use) across the 41 included studies was 0.71 (95% confidence interval: 0.64, 0.78). The corresponding pooled ORs were 0.58 (0.38, 0.90), 0.66 (0.57, 0.75), 0.71 (0.57, 0.89) and 0.83 (0.67, 1.04) for

SUBMITTER: Ma Y 

PROVIDER: S-EPMC3524177 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature