Interaction signatures stabilizing the NAD(P)-binding Rossmann fold: a structure network approach.

ABSTRACT: The fidelity of the folding pathways being encoded in the amino acid sequence is met with challenge in instances where proteins with no sequence homology, performing different functions and no apparent evolutionary linkage, adopt a similar fold. The problem stated otherwise is that a limited fold space is available to a repertoire of diverse sequences. The key question is what factors lead to the formation of a fold from diverse sequences. Here, with the NAD(P)-binding Rossmann fold domains as a case study and using the concepts of network theory, we have unveiled the consensus structural features that drive the formation of this fold. We have proposed a graph theoretic formalism to capture the structural details in terms of the conserved atomic interactions in global milieu, and hence ext

SUBMITTER: Bhattacharyya M 

PROVIDER: S-EPMC3524241 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature