Statistical discovery of site inter-dependencies in sub-molecular hierarchical protein structuring.

ABSTRACT:

Unlabelled

Background

Much progress has been made in understanding the 3D structure of proteins using methods such as NMR and X-ray crystallography. The resulting 3D structures are extremely informative, but do not always reveal which sites and residues within the structure are of special importance. Recently, there are indications that multiple-residue, sub-domain structural relationships within the larger 3D consensus structure of a protein can be inferred from the analysis of the multiple sequence alignment data of a protein family. These intra-dependent clusters of associated sites are used to indicate hierarchical inter-residue relationships within the 3D structure. To reveal the patterns of associations among individual amino acids or sub-domain components within the

SUBMITTER: Durston KK 

PROVIDER: S-EPMC3524763 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature