Evolution of flux control in the glucosinolate pathway in Arabidopsis thaliana.

ABSTRACT: Network characteristics of biochemical pathways are believed to influence the rate of evolutionary change in constituent enzymes. One characteristic that may affect rate heterogeneity is control of the amount of product produced by a biochemical pathway or flux control. In particular, theoretical analyses suggest that adaptive substitutions should be concentrated in the enzyme(s) that exert the greatest control over flux. Although a handful of studies have found a correlation between position in a pathway and evolutionary rate, these investigations have not examined the relationship between evolutionary rate and flux control. Given that genes with greater control will experience stronger selection and that the probability of fixation is proportional to the selective advantage, we ask the f

SUBMITTER: Olson-Manning CF 

PROVIDER: S-EPMC3525143 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature