Haplotype structure and linkage disequilibrium in chemokine and chemokine receptor genes.

ABSTRACT: To dissect the haplotype structure of candidate genes for disease association studies, it is important to understand the nature of genetic variation at these loci in different populations. We present a survey of haplotype structure and linkage disequilibrium of chemokine and chemokine receptor genes in 11 geographically-distinct population samples (n=728). Chemokine proteins are involved in intercellular signalling and the immune response. These molecules are important modulators of human immunodeficiency virus (HIV)-1 infection and the progression of the acquired immune deficiency syndrome, tumour development and the metastatic process of cancer. To study the extent of genetic variation in this gene family, single nucleotide polymorphisms (SNPs) from 13 chemokine and chemokine receptor ge

SUBMITTER: Clark VJ 

PROVIDER: S-EPMC3525265 | biostudies-literature | 2004 May

REPOSITORIES: biostudies-literature