The genomic distribution of population substructure in four populations using 8,525 autosomal SNPs.

ABSTRACT: Understanding the nature of evolutionary relationships among persons and populations is important for the efficient application of genome science to biomedical research. We have analysed 8,525 autosomal single nucleotide polymorphisms (SNPs) in 84 individuals from four populations: African-American, European-American, Chinese and Japanese. Individual relationships were reconstructed using the allele sharing distance and the neighbour-joining tree making method. Trees show clear clustering according to population, with the root branching from the African-American clade. The African-American cluster is much less star-like than European-American and East Asian clusters, primarily because of admixture. Furthermore, on the East Asian branch, all ten Chinese individuals cluster together and all

SUBMITTER: Shriver MD 

PROVIDER: S-EPMC3525267 | biostudies-literature | 2004 May

REPOSITORIES: biostudies-literature