Sex-specific differences in retinal nerve fiber layer thinning after acute optic neuritis.

ABSTRACT:

Objective

The primary objective of this study was to explore the potential influence of gender on recovery from optic neuritis (ON) by determining whether differences in retinal nerve fiber layer (RNFL) thickness can be detected between men and women 6 months after an ON event.

Methods

In this prospective cohort study, 39 men and 105 women with acute ON underwent repeat visual and optical coherence tomography (OCT) testing. The main outcome measures were change in RNFL measurements for male and female patients 6 months after ON.

Results

Men were older (mean age = 39 years) than women (35 years) (p = 0.05) in this study, and more men (62%) than women (41%) had a diagnosis of relapsing-remitting multiple sclerosis (MS) (p = 0.02). Because age and MS subtype were 2 signi

SUBMITTER: Costello F 

PROVIDER: S-EPMC3525310 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature