Hormone therapy and Alzheimer disease dementia: new findings from the Cache County Study.

ABSTRACT:

Objectives

Observational studies suggest reduced risk of Alzheimer disease (AD) in users of hormone therapy (HT), but trials show higher risk. We examined whether the association of HT with AD varies with timing or type of HT use.

Methods

Between 1995 and 2006, the population-based Cache County Study followed 1,768 women who had provided a detailed history on age at menopause and use of HT. During this interval, 176 women developed incident AD. Cox proportional hazard models evaluated the association of HT use with AD, overall and in relation to timing, duration of use, and type (opposed vs unopposed) of HT.

Results

Women who used any type of HT within 5 years of menopause had 30% less risk of AD (95% confidence interval 0.49-0.99), especially if use was for 10 or mor

SUBMITTER: Shao H 

PROVIDER: S-EPMC3525314 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature