OASIS: an automated program for global investigation of bacterial and archaeal insertion sequences.

ABSTRACT: Insertion sequences (ISs) are simple transposable elements present in most bacterial and archaeal genomes and play an important role in genomic evolution. The recent expansion of sequenced genomes offers the opportunity to study ISs comprehensively, but this requires efficient and accurate tools for IS annotation. We have developed an open-source program called OASIS, or Optimized Annotation System for Insertion Sequences, which automatically annotates ISs within sequenced genomes. OASIS annotations of 1737 bacterial and archaeal genomes offered an unprecedented opportunity to examine IS evolution. At a broad scale, we found that most IS families are quite widespread; however, they are not present randomly across taxa. This may indicate differential loss, barriers to exchange and/or insuff

SUBMITTER: Robinson DG 

PROVIDER: S-EPMC3526298 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature