Gene family assignment-free comparative genomics.

ABSTRACT:

Background

The comparison of relative gene orders between two genomes offers deep insights into functional correlations of genes and the evolutionary relationships between the corresponding organisms. Methods for gene order analyses often require prior knowledge of homologies between all genes of the genomic dataset. Since such information is hard to obtain, it is common to predict homologous groups based on sequence similarity. These hypothetical groups of homologous genes are called gene families.

Results

This manuscript promotes a new branch of gene order studies in which prior assignment of gene families is not required. As a case study, we present a new similarity measure between pairs of genomes that is related to the breakpoint distance. We propose an exact and a heur

SUBMITTER: Doerr D 

PROVIDER: S-EPMC3526435 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature