Genome-wide association between DNA methylation and alternative splicing in an invertebrate.

ABSTRACT:

Background

Gene bodies are the most evolutionarily conserved targets of DNA methylation in eukaryotes. However, the regulatory functions of gene body DNA methylation remain largely unknown. DNA methylation in insects appears to be primarily confined to exons. Two recent studies in Apis mellifera (honeybee) and Nasonia vitripennis (jewel wasp) analyzed transcription and DNA methylation data for one gene in each species to demonstrate that exon-specific DNA methylation may be associated with alternative splicing events. In this study we investigated the relationship between DNA methylation, alternative splicing, and cross-species gene conservation on a genome-wide scale using genome-wide transcription and DNA methylation data.

Results

We generated RNA deep sequencing data (RNA

SUBMITTER: Flores K 

PROVIDER: S-EPMC3526459 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature