Quality assessment of protein model-structures based on structural and functional similarities.

ABSTRACT:

Background

Experimental determination of protein 3D structures is expensive, time consuming and sometimes impossible. A gap between number of protein structures deposited in the World Wide Protein Data Bank and the number of sequenced proteins constantly broadens. Computational modeling is deemed to be one of the ways to deal with the problem. Although protein 3D structure prediction is a difficult task, many tools are available. These tools can model it from a sequence or partial structural information, e.g. contact maps. Consequently, biologists have the ability to generate automatically a putative 3D structure model of any protein. However, the main issue becomes evaluation of the model quality, which is one of the most important challenges of structural biology.

Results

SUBMITTER: Konopka BM 

PROVIDER: S-EPMC3526563 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature