The efficacy and tolerability of 'polypills': meta-analysis of randomised controlled trials.

ABSTRACT:

Background

To assess the blood pressure and lipid-lowering efficacy and tolerability of 'polypills' used in cardiovascular disease prevention trials.

Methodology/principal findings

Systematic review and meta-analysis.

Search strategy

The Cochrane Central Register of Controlled Trials, Medline, and PubMed databases were searched for eligible trials. Study inclusion criteria: Randomised controlled trials of at least six weeks duration, which compared a 'polypill' (that included at least one anti-hypertensive and one lipid-lowering medication) with a placebo (or one active component).

Outcome measures

Change from baseline in systolic and diastolic blood pressures, and total and LDL-cholesterol; discontinuation of study medication and reported adverse effects. Of 4

SUBMITTER: Elley CR 

PROVIDER: S-EPMC3526586 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature