An equation to estimate the concentration of serum apolipoprotein B.

ABSTRACT:

Background

Several large prospective studies have demonstrated that apolipoprotein B (apoB) has greater value in predicting cardiovascular risk than any other lipid measurements. Currently, however, serum apoB levels are not routinely measured, because of the additional cost. The aim of this study was to develop an equation to estimate apoB from conventional lipid measurements including total cholesterol, HDL cholesterol, and triglycerides.

Methods

Data from a total of 78,127 subjects (47,057 men and 31,070 women), aged 15 to 88 years (mean age 41.8 years) were reviewed to develop an apoB equation. Additional datasets from the same institution and the NHANES obtained in 2007-2008 were used for internal (n = 73,445) and external validation (n = 3,097), respectively.

Result

SUBMITTER: Hwang YC 

PROVIDER: S-EPMC3526603 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature