Hybrid mathematical model of cardiomyocyte turnover in the adult human heart.

ABSTRACT:

Rationale

The capacity for cardiomyocyte regeneration in the healthy adult human heart is fundamentally relevant for both myocardial homeostasis and cardiomyopathy therapeutics. However, estimates of cardiomyocyte turnover rates conflict greatly, with a study employing C14 pulse-chase methodology concluding 1% annual turnover in youth declining to 0.5% with aging and another using cell population dynamics indicating substantial, age-increasing turnover (4% increasing to 20%).

Objective

Create a hybrid mathematical model to critically examine rates of cardiomyocyte turnover derived from alternative methodologies.

Methods and results

Examined in isolation, the cell population analysis exhibited severe sensitivity to a stem cell expansion exponent (20% variation causing

SUBMITTER: Elser JA 

PROVIDER: S-EPMC3526650 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature