Spinal cord tolerance to single-session uniform irradiation in pigs: implications for a dose-volume effect.

ABSTRACT:

Background and purpose

This study was performed to test the hypothesis that spinal cord radiosensitivity is significantly modified by uniform versus laterally non-uniform dose distributions.

Materials and methods

A uniform dose distribution was delivered to a 4.5-7.0 cm length of cervical spinal cord in 22 mature Yucatan minipigs for comparison with a companion study in which a laterally non-uniform dose was given [1]. Pigs were allocated into four dose groups with mean maximum spinal cord doses of 17.5 ± 0.1 Gy (n=7), 19.5 ± 0.2 Gy (n=6), 22.0 ± 0.1 Gy (n=5), and 24.1 ± 0.2 Gy (n=4). The study endpoint was motor neurologic deficit determined by a change in gait within one year. Spinal cord sections were stained with a Luxol fast blue/periodic acid Schiff combination.

Res

SUBMITTER: Medin PM 

PROVIDER: S-EPMC3526692 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature