Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme.

ABSTRACT:

Background

Good bone and joint health is essential for the physical tasks of daily living and poorer indicators of physical capability in older adults have been associated with increased mortality rates. Genetic variants of indicators of bone and joint health may be associated with measures of physical capability.

Methods

As part of the Healthy Ageing across the Life Course (HALCyon) programme, men and women aged between 52 and 90+ years from six UK cohorts were genotyped for a polymorphism associated with serum calcium (rs1801725, CASR), two polymorphisms associated with bone mineral density (BMD) (rs2941740, ESR1 and rs9594759, RANKL) and one associated with osteoarthritis risk rs3815148 (COG5). Meta-analysis was used to pool within-study effects of the associations betwee

SUBMITTER: Alfred T 

PROVIDER: S-EPMC3526776 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature