Population Genomics of sub-saharan Drosophila melanogaster: African diversity and non-African admixture.

ABSTRACT: Drosophila melanogaster has played a pivotal role in the development of modern population genetics. However, many basic questions regarding the demographic and adaptive history of this species remain unresolved. We report the genome sequencing of 139 wild-derived strains of D. melanogaster, representing 22 population samples from the sub-Saharan ancestral range of this species, along with one European population. Most genomes were sequenced above 25X depth from haploid embryos. Results indicated a pervasive influence of non-African admixture in many African populations, motivating the development and application of a novel admixture detection method. Admixture proportions varied among populations, with greater admixture in urban locations. Admixture levels also varied across the genome, wi

SUBMITTER: Pool JE 

PROVIDER: S-EPMC3527209 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature