Total synthesis of Septocylindrin B and C-terminus modified analogues.

ABSTRACT: The total synthesis is reported of the peptaibol Septocylindrin B which is related to the well documented channel forming peptaibol antibiotic Alamethicin. Several analogues were synthesized with a modified C-terminus, to investigate the SAR of the terminal residue Phaol. All these peptides were tested for their membrane perturbation properties by fluorescent dye leakage assay and for their antibacterial activity.

SUBMITTER: Nelissen J 

PROVIDER: S-EPMC3527430 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature