The hemodynamic basis for positional- and inter-fetal dependent effects in dual arterial supply of mouse pregnancies.

ABSTRACT: In mammalian pregnancy, maternal cardiovascular adaptations must match the requirements of the growing fetus(es), and respond to physiologic and pathologic conditions. Such adaptations are particularly demanding for mammals bearing large-litter pregnancies, with their inherent conflict between the interests of each individual fetus and the welfare of the entire progeny. The mouse is the most common animal model used to study development and genetics, as well as pregnancy-related diseases. Previous studies suggested that in mice, maternal blood flow to the placentas occurs via a single arterial uterine loop generated by arterial-arterial anastomosis of the uterine artery to the uterine branch of the ovarian artery, resulting in counter bi-directional blood flow. However, we provide here exp

SUBMITTER: Raz T 

PROVIDER: S-EPMC3527527 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature