Ontology highlight
ABSTRACT:
SUBMITTER: Serva A
PROVIDER: S-EPMC3527550 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PloS one 20121220 12
miRNA cluster miR-17-92 is known as oncomir-1 due to its potent oncogenic function. miR-17-92 is a polycistronic cluster that encodes 6 miRNAs, and can both facilitate and inhibit cell proliferation. Known targets of miRNAs encoded by this cluster are largely regulators of cell cycle progression and apoptosis. Here, we show that miRNAs encoded by this cluster and sharing the seed sequence of miR-17 exert their influence on one of the most essential cellular processes - endocytic trafficking. By ...[more]