Establishment of a TGFβ-induced post-transcriptional EMT gene signature.

ABSTRACT: A major challenge in the clinical management of human cancers is to accurately stratify patients according to risk and likelihood of a favorable response. Stratification is confounded by significant phenotypic heterogeneity in some tumor types, often without obvious criteria for subdivision. Despite intensive transcriptional array analyses, the identity and validation of cancer specific 'signature genes' remains elusive, partially because the transcriptome does not mirror the proteome. The simplification associated with transcriptomic profiling does not take into consideration changes in the relative expression among transcripts that arise due to post-transcriptional regulatory events. We have previously shown that TGFβ post-transcriptionally regulates epithelial-mesenchymal transition (EM

SUBMITTER: Hussey GS 

PROVIDER: S-EPMC3527574 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature