Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice.

ABSTRACT:

Background

Beneficial effects of nicorandil on the treatment of hypertensive heart failure (HF) and ischemic heart disease have been suggested. However, whether nicorandil has inhibitory effects on HF and ventricular arrhythmias caused by the activation of G protein alpha q (Gα(q)) -coupled receptor (GPCR) signaling still remains unknown. We investigated these inhibitory effects of nicorandil in transgenic mice with transient cardiac expression of activated Gα(q) (Gα(q)-TG).

Methodology/principal findings

Nicorandil (6 mg/kg/day) or vehicle was chronically administered to Gα(q)-TG from 8 to 32 weeks of age, and all experiments were performed in mice at the age of 32 weeks. Chronic nicorandil administration prevented the severe reduction of left ventricular fractional shorten

SUBMITTER: Hirose M 

PROVIDER: S-EPMC3527603 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature