Identification of novel cholesteatoma-related gene expression signatures using full-genome microarrays.

ABSTRACT:

Background

Cholesteatoma is a gradually expanding destructive epithelial lesion within the middle ear. It can cause extensive local tissue destruction in the temporal bone and can initially lead to the development of conductive hearing loss via ossicular erosion. As the disease progresses, sensorineural hearing loss, vertigo or facial palsy may occur. Cholesteatoma may promote the spread of infection through the tegmen of the middle ear and cause meningitis or intracranial infections with abscess formation. It must, therefore, be considered as a potentially life-threatening middle ear disease.

Methods and findings

In this study, we investigated differentially expressed genes in human cholesteatomas in comparison to regular auditory canal skin using Whole Human Genome Microar

SUBMITTER: Klenke C 

PROVIDER: S-EPMC3527606 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature