Survival features of EBV-stabilized cells from centenarians: morpho-functional and transcriptomic analyses.

ABSTRACT: In the present work, we analyzed the survival features of six different Epstein-Barr virus (EBV)-stabilized lymphoid cell lines obtained from adult subjects and from subjects of more than 95 years. For the first, we found that lymphoid B cells from centenarians were more resistant to apoptosis induction and displayed a more developed lysosomal compartment, the most critical component of phagic machinery, in comparison with lymphoid B cells from adult subjects. In addition, cells from centenarians were capable of engulfing and digesting other cells, i.e., their siblings (even entire cells), whereas lymphoid cells from "control samples", i.e., from adults, did not. This behavior was improved by nutrient deprivation but, strikingly, it was unaffected by the autophagy-modulating drug, rapamyci

SUBMITTER: Matarrese P 

PROVIDER: S-EPMC3528377 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature