Early adversity in chronic depression: clinical correlates and response to pharmacotherapy.

ABSTRACT:

Background

There is growing evidence suggesting that early adversity may be a marker for a distinct pathway to major depressive disorder (MDD). We examined associations between childhood adversity and a broad variety of clinical characteristics and response to pharmacotherapy in a large sample of patients with chronic forms of MDD.

Methods

Subjects included 808 patients with chronic forms of MDD (chronic MDD, double depression, or recurrent MDD with incomplete recovery between episodes and a total continuous duration of >2 years) who were enrolled in a 12-week open-label trial of algorithm-guided pharmacotherapy. Baseline assessments included a semi-structured diagnostic interview, and clinician- and self-rated measures of depressive symptoms, social functioning, depressotyp

SUBMITTER: Klein DN 

PROVIDER: S-EPMC3528400 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature