Brain region-specific altered expression and association of mitochondria-related genes in autism.

ABSTRACT:

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Background

Mitochondrial dysfunction (MtD) has been observed in approximately five percent of children with autism spectrum disorders (ASD). MtD could impair highly energy-dependent processes such as neurodevelopment, thereby contributing to autism. Most of the previous studies of MtD in autism have been restricted to the biomarkers of energy metabolism, while most of the genetic studies have been based on mutations in the mitochondrial DNA (mtDNA). Despite the mtDNA, most of the proteins essential for mitochondrial replication and function are encoded by the genomic DNA; so far, there have been very few studies of those genes. Therefore, we carried out a detailed study involving gene expression and genetic association studies of genes related to diverse mitochon

SUBMITTER: Anitha A 

PROVIDER: S-EPMC3528421 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature