Cognitive deficits in schizophrenia: an updated metanalysis of the scientific evidence.

ABSTRACT:

Background

This is an update of a previous meta-analysis published in 2005.

Methods

It includes the data published up to march 2010 for a total of 247 papers and 18,300 cases. Cognitive deficits are examined in 5 different domains: Memory functioning (128 studies), Global cognitive functioning (131 studies), Language (70 studies), Executive function (67 studies), Attention (76 studies). Only controlled studies were included: patients vs. normal subjects.

Results

Results evidence that in all domains and in all different analyses performed within each domain, patients show a significant reduction of cognitive efficiency with respect to normal subjects. The between studies heterogeneity is very high in almost all domains. There are various sources of this heterogeneity (

SUBMITTER: Fioravanti M 

PROVIDER: S-EPMC3528440 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature