Integrative analysis of the zinc finger transcription factor Lame duck in the Drosophila myogenic gene regulatory network.

ABSTRACT: Contemporary high-throughput technologies permit the rapid identification of transcription factor (TF) target genes on a genome-wide scale, yet the functional significance of TFs requires knowledge of target gene expression patterns, cooperating TFs, and cis-regulatory element (CRE) structures. Here we investigated the myogenic regulatory network downstream of the Drosophila zinc finger TF Lame duck (Lmd) by combining both previously published and newly performed genomic data sets, including ChIP sequencing (ChIP-seq), genome-wide mRNA profiling, cell-specific expression patterns of putative transcriptional targets, analysis of histone mark signatures, studies of TF cooccupancy by additional mesodermal regulators, TF binding site determination using protein binding microarrays (PBMs), and

SUBMITTER: Busser BW 

PROVIDER: S-EPMC3528522 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature