Substituted imidazo[1,2-a]pyridines as β-strand peptidomimetics.

ABSTRACT: New conformationally extended dipeptide surrogates based on an imidazo[1,2-a]pyridine scaffold are described. Efficient synthesis and incorporation into host peptides affords structures with native side-chain functionality and hydrogen bonding elements on one face of the backbone. Structural analysis by NMR suggests that model peptidomimetics adopt a β-strand-like conformation in solution.

SUBMITTER: Kang CW 

PROVIDER: S-EPMC3528799 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature