Efficient associative memory storage in cortical circuits of inhibitory and excitatory neurons.

ABSTRACT: Many features of synaptic connectivity are ubiquitous among cortical systems. Cortical networks are dominated by excitatory neurons and synapses, are sparsely connected, and function with stereotypically distributed connection weights. We show that these basic structural and functional features of synaptic connectivity arise readily from the requirement of efficient associative memory storage. Our theory makes two fundamental predictions. First, we predict that, despite a large number of neuron classes, functional connections between potentially connected cells must be realized with <50% probability if the presynaptic cell is excitatory and >50% probability if the presynaptic cell is inhibitory. Second, we establish a unique relation between probability of connection and coefficient of var

SUBMITTER: Chapeton J 

PROVIDER: S-EPMC3529061 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature