Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2.

ABSTRACT: Basic leucine zipper (bZip) transcription factors regulate cellular gene expression in response to a variety of extracellular signals and nutrient cues. Although the bZip domain is widely known to play significant roles in DNA binding and dimerization, recent studies point to an additional role for this motif in the recruitment of the transcriptional apparatus. For example, the cAMP response element binding protein (CREB)-regulated transcriptional coactivator (CRTC) family of transcriptional coactivators has been proposed to promote the expression of calcium and cAMP responsive genes, by binding to the CREB bZip in response to extracellular signals. Here we show that the CREB-binding domain (CBD) of CRTC2 folds into a single isolated 28-residue helix that seems to be critical for its inter

SUBMITTER: Luo Q 

PROVIDER: S-EPMC3529076 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature