Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.

ABSTRACT:

Background

We performed a genome-wide association study (GWAS) to identify common risk variants for schizophrenia.

Methods

The discovery scan included 1606 patients and 1794 controls from Ireland, using 6,212,339 directly genotyped or imputed single nucleotide polymorphisms (SNPs). A subset of this sample (270 cases and 860 controls) was subsequently included in the Psychiatric GWAS Consortium-schizophrenia GWAS meta-analysis.

Results

One hundred eight SNPs were taken forward for replication in an independent sample of 13,195 cases and 31,021 control subjects. The most significant associations in discovery, corrected for genomic inflation, were (rs204999, p combined = 1.34 × 10(-9) and in combined samples (rs2523722 p combined = 2.88 × 10(-16)) mapped to the major his

SUBMITTER: Irish Schizophrenia Genomics Consortium and the Wellcome Trust Case Control Consortium 2 

PROVIDER: S-EPMC3529467 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature