Toxicogenomic profiles in relation to maternal immunotoxic exposure and immune functionality in newborns.

ABSTRACT: A crucial period for the development of the immune system occurs in utero. This results in a high fetal vulnerability to immunotoxic exposure, and indeed, immunotoxic effects have been reported, demonstrating negative effects on immune-related health outcomes and immune functionality. Within the NewGeneris cohort BraMat, a subcohort of the Norwegian Mother and Child Cohort Study (MoBa), immunotoxicity was demonstrated for polychlorinated biphenyls and dioxins, showing associations between estimated maternal intake levels and reduced measles vaccination responses in the offspring at the age of 3. The present study aimed to investigate this link at the transcriptomic level within the same BraMat cohort. To this end, whole-genome gene expression in cord blood was investigated and found to be

SUBMITTER: Hochstenbach K 

PROVIDER: S-EPMC3529642 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature