Prospective randomized crossover evaluation of three anesthetic regimens for painful procedures in children with cancer.

ABSTRACT:

Objective

To identify the most effective sedation regimen for bone marrow aspiration and lumbar puncture procedures with a prospective trial of 3 combinations of sedation/analgesia.

Study design

In this double-blind crossover study, we randomly assigned 162 children with acute lymphoblastic leukemia or lymphoblastic lymphoma to receive fentanyl 1 mcg/kg, fentanyl 0.5 mcg/kg, or placebo, in addition to propofol and topical anesthetic for 355 procedures.

Results

We found no significant differences among the 3 regimens in the frequency of pain (pain score > 0) or severe pain (pain score ≥ 5) during recovery, or a >20% increase in hemodynamic/respiratory variables during anesthesia. Treatment with fentanyl 1 mcg/kg was associated with a lower frequency of movement during

SUBMITTER: Anghelescu DL 

PROVIDER: S-EPMC3529769 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature