Ontology highlight
ABSTRACT:
SUBMITTER: Cordero RJ
PROVIDER: S-EPMC3529781 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Cordero Radames J B RJ Pontes Bruno B Frases Susana S Nakouzi Antonio S AS Nimrichter Leonardo L Rodrigues Marcio L ML Viana Nathan B NB Casadevall Arturo A
Journal of immunology (Baltimore, Md. : 1950) 20121210 1
Abs to microbial capsules are critical for host defense against encapsulated pathogens, but very little is known about the effects of Ab binding on the capsule, apart from producing qualitative capsular reactions ("quellung" effects). A problem in studying Ab-capsule interactions is the lack of experimental methodology, given that capsules are fragile, highly hydrated structures. In this study, we pioneered the use of optical tweezers microscopy to study Ab-capsule interactions. Binding of prote ...[more]