Validating imaging biomarkers of cerebral edema in patients with severe ischemic stroke.

ABSTRACT:

Background

There is no validated neuroimaging marker for quantifying brain edema. We sought to test whether magnetic resonance imaging (MRI)-based metrics would reliably change during the early subacute period in a manner consistent with edema and whether they would correlate with relevant clinical endpoints.

Methods

Serial MRI studies from patients in the Echoplanar Imaging Thrombolytic Evaluation Trial with initial diffusion-weighted imaging (DWI) lesion volume >82 cm(3) were analyzed. Two independent readers outlined the hemisphere and lateral ventricle on the involved side and calculated respective volumes at baseline and days 3 to 5. We assessed interrater agreement, volume change between scans, and the association of volume change with early neurologic deterioration (N

SUBMITTER: Yoo AJ 

PROVIDER: S-EPMC3529850 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature