Brain and circulating levels of Aβ1-40 differentially contribute to vasomotor dysfunction in the mouse brain.

ABSTRACT:

Background and purpose

Amyloid-β (Aβ), a peptide that accumulates in the brain and circulates in the blood of patients with Alzheimer disease, alters the regulation of cerebral blood flow and may contribute to the brain dysfunction underlying the dementia. However, the contributions of brain and circulating Aβ1-40 to the vascular dysfunction have not been elucidated.

Methods

We used transgenic mice overexpressing mutated forms of the amyloid precursor protein in which Aβ1-40 is elevated in blood and brain (Tg-2576) or only in brain (Tg-SwDI). Mice were equipped with a cranial window, and the increase in cerebral blood flow induced by neural activity (whisker stimulation), or by topical application of endothelium-dependent vasodilators, was assessed by laser-Doppler flowmetry

SUBMITTER: Park L 

PROVIDER: S-EPMC3530010 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature