Human rhinovirus species and season of infection determine illness severity.

ABSTRACT:

Rationale

Human rhinoviruses (HRVs) consist of approximately 160 types that cause a wide range of clinical outcomes, including asymptomatic infections, common colds, and severe lower respiratory illnesses.

Objectives

To identify factors that influence the severity of HRV illnesses.

Methods

HRV species and types were determined in 1,445 nasal lavages that were prospectively collected from 209 infants participating in a birth cohort who had at least one HRV infection. Questionnaires were used during each illness to identify moderate to severe illnesses (MSI).

Measurements and main results

Altogether, 670 HRV infections were identified, and 519 of them were solitary infections (only one HRV type). These 519 viruses belonged to 93 different types of three species:

SUBMITTER: Lee WM 

PROVIDER: S-EPMC3530215 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature