Multi-tissue microarray analysis identifies a molecular signature of regeneration.

ABSTRACT: The inability to functionally repair tissues that are lost as a consequence of disease or injury remains a significant challenge for regenerative medicine. The molecular and cellular processes involved in complete restoration of tissue architecture and function are expected to be complex and remain largely unknown. Unlike humans, certain salamanders can completely regenerate injured tissues and lost appendages without scar formation. A parsimonious hypothesis would predict that all of these regenerative activities are regulated, at least in part, by a common set of genes. To test this hypothesis and identify genes that might control conserved regenerative processes, we performed a comprehensive microarray analysis of the early regenerative response in five regeneration-competent tissues fr

SUBMITTER: Mercer SE 

PROVIDER: S-EPMC3530543 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature