A second-generation assembly of the Drosophila simulans genome provides new insights into patterns of lineage-specific divergence.

ABSTRACT: We create a new assembly of the Drosophila simulans genome using 142 million paired short-read sequences and previously published data for strain w(501). Our assembly represents a higher-quality genomic sequence with greater coverage, fewer misassemblies, and, by several indexes, fewer sequence errors. Evolutionary analysis of this genome reference sequence reveals interesting patterns of lineage-specific divergence that are different from those previously reported. Specifically, we find that Drosophila melanogaster evolves faster than D. simulans at all annotated classes of sites, including putatively neutrally evolving sites found in minimal introns. While this may be partly explained by a higher mutation rate in D. melanogaster, we also find significant heterogeneity in rates of evoluti

SUBMITTER: Hu TT 

PROVIDER: S-EPMC3530686 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature