Absolute risk prediction of second primary thyroid cancer among 5-year survivors of childhood cancer.

ABSTRACT:

Purpose

We developed three absolute risk models for second primary thyroid cancer to assist with long-term clinical monitoring of childhood cancer survivors.

Patients and methods

We used data from the Childhood Cancer Survivor Study (CCSS) and two nested case-control studies (Nordic CCSS; Late Effects Study Group). Model M1 included self-reported risk factors, model M2 added basic radiation and chemotherapy treatment information abstracted from medical records, and model M3 refined M2 by incorporating reconstructed radiation absorbed dose to the thyroid. All models were validated in an independent cohort of French childhood cancer survivors.

Results

M1 included birth year, initial cancer type, age at diagnosis, sex, and past thyroid nodule diagnosis. M2 added radiatio

SUBMITTER: Kovalchik SA 

PROVIDER: S-EPMC3530689 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature