EProS--a database and toolbox for investigating protein sequence-structure-function relationships through energy profiles.

ABSTRACT: Gaining information about structural and functional features of newly identified proteins is often a difficult task. This information is crucial for understanding sequence-structure-function relationships of target proteins and, thus, essential in comprehending the mechanisms and dynamics of the molecular systems of interest. Using protein energy profiles is a novel approach that can contribute in addressing such problems. An energy profile corresponds to the sequence of energy values that are derived from a coarse-grained energy model. Energy profiles can be computed from protein structures or predicted from sequences. As shown, correspondences and dissimilarities in energy profiles can be applied for investigations of protein mechanics and dynamics. We developed eProS (energy profile sui

SUBMITTER: Heinke F 

PROVIDER: S-EPMC3531212 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature